The synthesis of naturally occuring ecteinascidins

专利名称：The synthesis of naturally occuring

ecteinascidins and related compounds

发明人：Menchaca, Roberto,Martinez,

Valentin,Rodriguez, Alberto,Rodriguez,Natividad,Gallego, Pilar,Cuevas,

Carmen,Munt, Simon,Manzanares, Ignacio

申请号：EP10181699.9申请日：20030204公开号：EP2305689A1公开日：20110406

摘要：The present invention provides compounds of formula: wherein R and Rtogether with the carbon to which they are attached form a group of formula: whereeach X is independently selected from hydrogen or substituted or unsubstituted R', OR',-(C=O)R', substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy,substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substitutedor unsubstituted aryl, and substituted or unsubstituted aralkyl; wherein R' is selectedfrom the group consisting of H, OH, NO NH, SH, CN, halogen, C(=O)H, C(=O)CH, COH,COCH, C-C alkyl, alkenyl, alkynyl, aryl, aralkyl and heterocyclic; where R is a substituted orunsubstituted R', OR',-(C=O)R', substituted or unsubstituted alkyl, substituted orunsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted or unsubstitutedalkynyl, substituted or unsubstituted aryl, or substituted or unsubstituted aralkyl;wherein R' is selected from the group consisting of OH, NO, NH, SH, CN, halogen, C(=O)H,C(=O)CH, COH, COCH, C-C alkyl, alkenyl, alkynyl, aryl, aralkyl and heterocyclic; R is -OCH

and R is -OH or R and R together form a group -O-CH-O-; R is hydrogen, acyl, alkenyl, oralkyl-O-CO-; R is -H, OH or CN; X is -O- or -NH-; R and R are -OX, wherein each X isindependently selected from hydrogen, substituted or unsubstituted C-C alkyl,substituted or unsubstituted C-C alkenyl, substituted or unsubstituted CC alkynyl,substituted or unsubstituted aryl, and -C(=O)R' wherein R' is selected from hydrogen,OH, NO, NH, SH, CN, halogen, C-C alkyl, alkenyl, alkynyl, aryl, aralkyl, and heterocyclic.

申请人：Pharma Mar S.A.U.

地址：Avenida de los Reyes no.1, Poligono Industrial La Mina 28770 Colmenar Viejo(Madrid) ES

国籍：ES

代理机构：Gordon, Kirsteen Helen

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